Current Key Words: Duchenne, muscular dystrophy, dystrophin, muscles, degeneration
Combinations: Duchenne Muscular Dystrophy,
muscle degeneration, dystrophin degeneration
Operators: PUC Library Database
New Information: The combination most useful was "
muscle degeneration" which I used in the PUC Library Database. I learned that bone marrow stromal cells are being used to regenerate muscle tissues. The regeneration of muscle tissues can help reverse the effects of muscle degeneration for diseases like Duchenne Muscular Dystrophy. The bone marrow stromal cells are transplanted into the body from fetal cells (cells from aborted or still-born babies) which is causing a social dilemma about whether that is moral of not.
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New Key Words: bone marrow, stromal cells, muscle degeneration, muscles, muscle diseases, muscle regeneration, transplants
Combinations: bone marrow stromal cells, muscle degeneration diseases,
muscle regeneration transplants
Operators: PUC Library Database
New Information: The combination most useful was
"muscle regeneration transplants" which I used in the PUC Library Database. I learned that skeletal muscles that are damaged especially by muscle degeneration diseases like Duchenne Muscular Dystrophy are able to regenerate new muscle fibers. Muscle fibers are syncytial cells that have hundreds of nuclei in the cytoplasm of cells. The regeneration of muscle tissues depends on the coming together of cells that have only one nucleus or the piecing together of muscle fibers that are dying. The process creates new cells which is a social dilemma because the cells are transplanted into the body from fetal cells.
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Annotated Bibliographies
#1
Dezawa,
M., Ishikawa, H., Itokazu, Y., Yoshihara, T., Hoshino, M., Takeda, S., Ide, C.,
& Nabeshima, Y. (2005). Bone marrow stromal cells generate muscle cells and
repair muscle degeneration. Science,
309(5732), 314.
Summary:
The
article explain a new process to help regenerate muscle cells due to muscle
degeneration from degenerative diseases. The author explains how bone marrow
stromal cells are transplanted into the body to regenerate muscle cells. The stromal
cells are transplanted from fetal cells. The use of fetal cells is a social
controversial debate because the cells come from aborted or still born babies.
Assess:
The
source will be very useful when talking about finding a cure for Duchenne
Muscular Dystrophy. The authors are credible sources because they have done the
research themselves and have provided resources to back up their information
with. The source is mainly objective, but might have subtle bias.
Reflect:
I may
use the source when adding to my webtext phase three in order to add ways to do
more research and find a cure that I mentioned in my expansion google document.
The source is relevant to the time with the controversial issues and the research
done and has very credible information. The source did not change my view about
the topic.
#2
Tedesco,
F. S., Dellavalle, A., Diaz - Manera, J., Messina, G., & Cossu, G. (2010). Repairing
skeletal muscle: regenerative potential of skeletal muscle stem cells. Journal of Clinical Investigation, 120(1),
11.
Summary:
The
article talks about how skeletal muscles are damaged especially by muscle
degeneration diseases like Duchenne Muscular Dystrophy are able to regenerate
new muscle fibers. Muscle fibers are syncytial cells that have hundreds of
nuclei in the cytoplasm of cells. The regeneration of muscle tissues depends on
the coming together of cells that have only one nucleus or the piecing together
of muscle fibers that are dying. The process creates new cells which is a
social dilemma because the cells are transplanted into the body from fetal
cells.
Assess:
The
source will be very useful when adding to my phase three webtext revision that I
mentioned in the webtext expansion document about adding awareness sites about
finding cures for D.M.D. The authors establish credibility by being the authors
of the article, performing the research and study themselves, and by using
references to back up their information and conclusions. The source is objective,
but may have subtle bias.
Reflect:
I
could use the source when revising my webtext for the phase three final revision.
The source is relevant to the time period with research and the controversy of
using fetal cells for transplants for muscle regeneration. The source did not
change my view of the topic.
